What happens to a dog with MDR1?

11.12.2023 MDR1 gene defect

What is it?

The MDR1 gene defect is a hereditary disease that leads to drug hypersensitivity. The MDR1 gene defect is a defect in the MDR1 gene that can occur in some dog breeds and also in humans. It is suspected that the cause of the defect in dogs is a single animal that played a key role in establishing the Collie breed around the time of the 19th century. This genetic defect is therefore also occurring more frequently today in dogs that belong to the herding dog breed or that carry it genetically.

This genetic disease leads to a deficient or lacking synthesis of a certain protein (P-glycoprotein), which is an important component of the blood-brain barrier. The so-called MDR1 transporter forms a protective barrier for the brain at this boundary between the brain blood vessels and the cranial nerve tissue. The transporter is located as part of the blood-brain barrier on the surface of the endothelial cells (cells that line the walls of the blood vessels).

It protects the brain from toxins and drugs. In an animal with an MDR1 defect, the transporter is missing and protection is absent. As a result, severe brain and nerve damage can occur after the administration of certain substances, which can lead to death.

Which breeds are affected?

The MDR1 gene defect primarily affects herding dogs such as Collies, Border Collies, Australian Shepherds, Shetland Sheepdogs.

3 genotypes

The first possibility is that the MDR1 is (+/+), which means the animal is free of the defect and can produce the necessary protein just like any other breed. All substances can be administered here. The second possibility is that the animal has the MDR1 (+/-) genotype, meaning it was inherited heterozygous (one of two alleles is affected). The defect was only inherited from one parent and can be passed on. Side effects may occur when taking unwanted medication, but this is not inevitable. Dogs with this possibility should be treated like dogs that are MDR1 (-/-).

The third possibility is that the MDR1 is (-/-), which means the animal is homozygous for the defect (both alleles are defective). A functional MDR1 transport system is missing. The defect was inherited from both parents and will certainly be passed on. Certain substances must be avoided during therapy.

How can I determine whether my animal is affected?

Externally, affected dogs cannot be distinguished from healthy ones. In order to find out whether a dog is a carrier of the genetic defect, a genetic test must be carried out in a special laboratory. For this purpose, approximately 1 ml of blood is taken from the dog once.

What happens with such a genetic defect?

Since the protective mechanism for the blood-brain barrier is missing in an MDR1 genetic defect, these substances can enter the nervous system and accumulate there. The result is severe symptoms of poisoning, which can lead to death. Dogs with an MDR1 genetic defect can suffer side effects (depending on the active ingredient, from harmless to life-threatening) from many different active ingredients in medications even at normal doses, i.e. what is actually supposed to help can torment them and sometimes poison them fatally. Symptoms can include vomiting, disorientation, movement disorders, tremors, increased panting, unusual behavior (e.g. stress), etc.

Which substances are affected?

The intolerance affects both everyday medications prescribed by a veterinarian, such as certain antiparasitics (worming treatments, flea and tick repellents) or gastrointestinal medications, as well as certain antibiotics, heart medications, painkillers, anesthetic/sedative and emergency medications, and chemotherapy drugs, which are generally completely unproblematic for healthy dogs. Dogs should also be careful not to ingest horse manure when walking, as the horses could have been treated with an antiparasitic drug. The amount excreted here could trigger intolerance in a dog with the MDR1 gene defect.

Is CBD one of these substances?

CBD can also pass through the blood-brain barrier. It is suspected that it can cause severe brain poisoning in dogs with the genetic defect. However, more precise details are not yet known, as appropriate studies are still lacking. Therefore, you should refrain from administering CBD oil if you know or suspect that you have an MDR1 genetic defect.

What should I take instead?

CBD is often used by pet owners to calm down or relieve pain. Alternative to the effects of CBD: Joint support ArthroGreen Classic (item no. 285) is ideal for preventing diseases that affect the musculoskeletal system. ArthroGreen plus (item no. 554) is characterized by an additional portion of willow bark, which is said to have a pain-relieving effect in naturopathy.

Calming

In order to provide long-term support to stressed dogs in everyday life, the nerve food (item no. 358) was designed from plants with a calming healing effect. Bach flowers are a popular remedy for dealing with fear, inner restlessness, stress and other negative mental states. (Bach flowers S.O.S item no. 4166) Calma (item no. 2032) ensures relaxation in acute stress situations.

Fit-BARF Bio-Amaranth flakes 400g

Feed material for dogsTo supplement the daily ration at raw feeding.Amaranth is one of the oldest agricultural crops of humankind.It is not among the sweet grasses, such as normal grain varieties.It is one of the fox tail plants.This makes it to one of the pseudo-cereals.Amaranth is gluten-free and thus an excellent alternative for dogs who are fed grain free.- easily digestible- As an addition to fresh or canned meatComposition: 100% Bio- Amaranth flakes inspection DE-ÖKO-001 EU AgricultureAnalytical constituents: Crude protein 13.5%, crude fiber 2.5%Feeding recommendation: Pour the Fit-Barf Bio- Amaranth flakes with hot water, let it swell for at least 15 minutes and then feed with fresh or canned meat.Up to 10% of the total amount of feed as soaked flake.For soaking, the ratio 1 part flakes and at least 2 parts water is recommended.From 10g dry flake about 30g ready to eat flake.

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Complementary feed for dogs and cats.For the appropriate supply at raw feedingBM-yeast (brewer´s yeast bounded on malt rootlets) Brewer´s yeast contains biotin, folic acids, ferrous, zinc and trace elements which has a positive influence on the condition and resistence of skin and hair. Also the ability for regeneration of the single cells can be affected diet-related. Malt rootlets distinguish themselves by her content of slightly digestible carbohydrates, crude fiber and crude protein. Through their high content of crude fiber the seedling have a good dietary value.Composition: Malt rootlets, brewer´s yeast.Analytical constituents : Crude protein 30,0%, crude fat 2,0%, crude fiber 9,0%, crude ash 7,0%.Feeding recommendation: Daily cats/small dogs 1 measuring spoon, medium dogs 2 measuring spoons, large dogs 3 measuring spoons. 1 measuring spoon corresponds to about approx. 1,2g.

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Feed material for dogs and catsFor the appropriate supply at raw feedingThe proportion of animal fat should be 15-25% in the diet of the dog and the cat should be at about 10%. If your dog or cat is fed with lean meat, it uses proteins to produce energy. In this case, wastes will be generated that need to be digested by liver and kidneys. The strain on the metabolism increases. On the long term, this can lead to congestions of the excretory organs. In case of dogs or cats that are poorly using the feed or very underweight, special attention should be paid to the fat content of the meat.Composition: 100% pure bovine fat.Analytical constituents: 100% crude fat.Feeding recommendation: cats 2-5 g, small dogs approx. 10 g, medium-sized dogs approx. 10-40 g, large dogs approx. 40-80 g.Depending on activity and energy needs feeding can be adjusted.If fat is being fed for the first time, please note that the addition must be slowly increased to the desired amount. The cat or dog should be given enough time for this change and should be particularly monitored during this time. Only then you can decide, whether your pet can cope with the amount of fat being fed. It is important to consider each animal as an individual.

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Fit-BARF CerealMix 450 g

Complementary (flakes) feed for dogsTo supplement the daily ration when feeding raw or cooked meatIN BRIEF: Can my dog eat cereals? Yes, dogs are allowed to eat cereal! Most dogs find cereals super tasty.Fit-BARF CerealMix provides a healthy variety in your dog‘s bowl. It provides your dog with fiber, minerals, and vitamins. Dietary fiber aids digestion and can prevent constipation. rich in dietary fibersatiatingsuitable for dogs of all ages (young, adult, senior) and breedsComposition: oat flakes, corn flakes, millet flakes, puffed riceAnalystical constituents: crude protein 9.3%, crude fat 5.2%, crude fiber 2.1%, crude ash 1.1%Feeding recommendation: Up to 10% of the total feed quantity as soaked flakes. Soak cereal flakes with hot water (1 part flakes, 4 parts water) for approx. 30-60 min. and then mix into the feed. 10 g dry flakes are equivalent to approx. 30 g soaked flakes.

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Fit-BARF Cod Liver Oil 100 ml

Feed material for dogs and catsNatural source of omega-3 fatty acids and vitamin DFit-BARF Cod Liver Oil is a high-value supplier for omega-3-fatty acids and vitamin D. Omega-3-fatty acid (for example linolenic acid) are polyunsaturated fatty acids, which cannot be created itselves by the body. Thus they are called essential and must be fed to the organism with the nutrition. Vitamin D is important for the builing of the bones and the regulation of the calcium balance.Composition: 100% Cod liver oil.Feeding recommendation: 1-2 x per week. Small dogs, cats: 0,5 tsp. Midsize dogs: 1 tsp. Large dogs: 1.5 tsp. For daily feeding, we recommend a period of 4-6 weeks.After opening store in cool and dark place and use it within 6 weeks!

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Fit-BARF Feeding Oil 100 ml

Complementary feed for dogs and catsFit-Barf Feeding Oil is a purely natural basic oil and is generally intended as optimal energy carrier.Fit-BARF Feeding Oil is a mixture of high-grated cold-pressed vegetable oils. Cold-pressed, food-grade linseed oil forms the basis of this purely natural feeding oil. This admixed functional oils (evening primrose oil, wheat germ oil, pumpkin seed oil and argan oil) ensures the optimal, well-balanced maintenance with essential fatty acids. Through this combination of pure naturally ingredients Fit-BARF Feeding Oil is a high-concentrated energy source and similarly an origin of significant vital substances of selected oils in one product.Composition:Linseed oil, evening primrose oil, wheat germ oil, pumpkin seed oil, argan oil.Analytical constituents: Crude protein 0.1%, crude fat 99.6%, crude fiber 0.1%, crude ash 0.2.Feeding recommendation: Daily small dogs and cats 0.5 teaspoon, medium dogs 1 teaspoon, large dogs 1.5 teaspoons.After opening, keep cool and dark and use within 6 weeks!

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Fit-BARF Fruit 100 g

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Fit-BARF Greenshell Mussel 35 g

Feed material for dogs and catsNatural source for taurine and glycosaminoglycans - for the demand-oriented provision at feeding with raw meat, powderThe naturally very high taurine content of the greenshell mussel is a very pleasing aspect for cat owners. Cats in particular depend on a sufficient supply of this organic acid in their food, as they cannot produce taurine themselves and lose a large part of it through their excretions. Taurine is essential for cats. A deficiency can lead to severe impairments and physical damage.Fit-BARF Greenshell Mussel consists of New Zealand greenshell mussel powder (Perna canaliculus, freeze-dried, non-defatted mussel meat). In addition, the greenshell mussel provides important components of the body‘s own mucous membrane as a building block and can thus have a supportive effect on the functionality and elasticity of the urinary bladder and all other mucous membranes. Occasionally fed, the trace elements and vitamins contained in the greenshell mussel can have a positive effect on vitality, metabolism, nutritional imbalances and on stressed skin.Expert tip: Does your dog suffer from joint problems? Then take a look at ArthroGreen Classic. The herbal composition, proven for years, supports your beloved four-legged friend on his daily tours.Growing puppy? Here ArthroGreen Junior offers the nutrients for a safe step into the big, wide world.Composition: New Zealand greenshell mussel powder (Perna canaliculus, freeze-dried, non-defatted mussel meat) 100%Analytical constituents: crude protein 54,1%, crude fat 10,3%Feeding recommendation: Add daily to the feed. Cats: 0.5 g/5 kg body weight. Dogs: 0.5 g/10 kg body weight. 1 half tsp. corresponds to ca. 1.5 g.

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